迭代最近点算法的改进策略

迭代最近点（Iterative Closest Point, ICP）算法是一种最为常见的点云配准方法，虽然配准精度高，但收敛速度慢，对含噪声、覆盖率较低点云的配准效果不佳。鉴于此，本文提出3种ICP算法的改进方法。针对含噪声的点云，采用概率ICP算法来抑制噪声点对配准结果的影响，提高配准精度；为了提高点云配准速度，采用坐标ICP算法实现点云的快速配准；针对低覆盖率点云，采用盒子ICP算法实现配准，可以大大提高配准精度和速度。通过兔子点云配准实验表明，3种改进的ICP算法在点云配准精度和速度方面都有很大程度的提高，均为有效的点云配准方法。     

An immuno-wall microdevice exhibits rapid and sensitive detection of IDH1-R132H mutation specific to grade II and III gliomas

World Health Organization grade II and III gliomas most frequently occur in the central nervous system (CNS) in adults. Gliomas are not circumscribed; tumor edges are irregular and consist of tumor cells, normal brain tissue, and hyperplastic reactive glial cells. Therefore, the tumors are not fully resectable, resulting in recurrence, malignant progression, and eventual death. Approximately 69–80% of grade II and III gliomas harbor mutations in the isocitrate dehydrogenase 1 gene (IDH1), of which 83–90% are found to be the IDH1-R132H mutation. Detection of the IDH1-R132H mutation should help in the differential diagnosis of grade II and III gliomas from other types of CNS tumors and help determine the boundary between the tumor and normal brain tissue. In this study, we established a highly sensitive antibody-based device, referred to as the immuno-wall, to detect the IDH1-R132H mutation in gliomas. The immuno-wall causes an immunoreaction in microchannels fabricated using a photo-polymerizing polymer. This microdevice enables the analysis of the IDH1 status with a small sample within 15 min with substantially high sensitivity. Our results suggested that 10% content of the IDH1-R132H mutation in a sample of 0.33 μl volume, with 500 ng protein, or from 500 cells is theoretically sufficient for the analysis. The immuno-wall device will enable the rapid and highly sensitive detection of the IDH1-R132H mutation in routine clinical practice.     

A Gauss–Seidel type solver for the fast computation of input-constrained control systems

An important class of nonlinear control systems can be represented as the feedback interconnection of two parts: a linear time-invariant system and a block of decentralized nonlinearities. When the linear time-invariant part has a nontrivial feedthrough term or the nonlinearity has a feedback gain, control computation involves the online implementation of a multivariable algebraic loop which must be resolved at each sampling instant. The requirements for such online computation may result in several implementation issues, especially in real-time and embedded control applications. This paper considers the implementation of such algebraic loops arising from several input-constrained systems. The proposed solution algorithm is globally convergent for a very large class of feedthrough or feedback gains and shows promise for real-time and embedded control applications where a fast but approximate solution is of the essence.     

泛逻辑学理论——机制主义人工智能理论的逻辑基础

当前，世界各主要大国都把人工智能作为它们的国家战略。人工智能的发展正在快速改变着人类的生活方式和思想观念。在中国，有一小批研究者20多年来一直在基于辩证唯物主义潜心研究具有普适性的人工智能基础理论，包括智能的形成机制、逻辑基础、数学基础、协调机理、矛盾转化等。终于，他们各自建立了机制主义人工智能理论、泛逻辑学理论、因素空间理论、协调学、可拓学、集对分析等。其中，机制主义人工智能理论是基于智能形成机制的通用理论，它能把现有的结构主义、功能主义和行为主义三大流派有机地统一起来，使意识、情感、理智成为三位一体的关系；因素空间理论是机制主义人工智能理论的数学基础；泛逻辑学理论是机制主义人工智能理论的逻辑基础。本文介绍了泛逻辑学理论的基本思想、理论基础和应用方法，阐明它的理论意义和应用价值。特别需要指出的是，在广义概率论基础上建立的命题泛逻辑（包括刚性逻辑和柔性逻辑），可看成一个完整的命题级智能信息处理算子库，库中完整地包含了全部18种柔性信息处理模式（包括16种布尔信息处理模式），可用类型编码<a,b,e>来严格区分，用它可寻找到适合自己的信息处理算子完整簇来使用。在每一个信息处理模式中，各种不确定性的组合状态由不确定性程度属性编码<k,h,β,e>来严格区分，用它可在本信息处理模式的算子完整簇中精确选择具体的算子来使用。这表明柔性信息处理本质上是一把密码锁，它需要专门的密码<a,b,e>+<k,h,β,e>才能正常打开，不能乱点鸳鸯谱。通过只有18种模式，每种模式可以从最大算子连续变化到最小算子，已经证明了没有一个命题算子被遗漏。     

一类多叶解析函数族的性质

引入了一类由Cho-Kwon-Srivastava算子定义的新p-叶解析函数族.利用从属定理得到了此函数族上的从属关系、包含关系及一些卷积性质,推广了前人的一些结果.     

增加[Δ]算子的Gödel[n]值命题逻辑系统理论的平均真度

在添加了[Δ]算子Gödeln值命题逻辑系统中，给出了Gödel[n]值命题逻辑系统中有限理论的平均真度的定义，给出了该系统下的一些重要结论并给予证明，验证了在该系统下平均真度的一些基本性质，为进一步在该系统下研究平均真度奠定了基础。     

一例含葡萄糖-6-磷酸酶新突变的复合杂合突变致华人糖原累积症Ia型的遗传特点

目的　探讨1例糖原累积症Ia型（glycogen storage disease type Ia，GSD Ia）患者的临床特点及遗传机制。方法　详细收集患者临床资料，包括病史、体格检查、实验室检查结果。提取患者及其父母的外周血DNA，进行葡萄糖-6-磷酸酶催化亚基（glucose-6-phosphatase catalytic subunit，G6PC）基因5个外显子测序，对新突变进行蛋白功能预测。结果　患者为27岁男性，有低血糖、高乳酸血症、高尿酸血症和高脂血症的典型临床表现，肝穿刺活检支持GSD Ia。患者G6PC基因第2个外显子检测到c.248G＞A（p.R83H）错义突变，第5个外显子检测到c.674T＞C（p.L225P）错义突变，患者父亲和母亲分别是携带c.674T＞C（p.L225P）及c.248G＞A（p.R83H）突变的杂合子。采用Polyphen 2和SIFT软件对新发现的c.674T＞C（p.L225P）突变蛋白功能进行预测，提示为致病突变，可能损害葡萄糖-6-磷酸酶蛋白功能。结论　G6PC基因的复合杂合突变是本例GSD Ia患者的致病基础，发现G6PC基因新的致病突变，拓宽了华人GSD Ia的致病基因谱。     

Morphological enhancement of microscopy mineral image using opening‐ and closing‐based toggle operator

To enhance unclear microscopy mineral images, an algorithm based on toggle operator using opening and closing is proposed in this paper. Firstly, the specified toggle operator using opening and closing through designing the selection rules is analysed. Secondly, after importing the multiscale theory into the specified toggle operator, useful mineral image features, especially the mineral details, are extracted using the multiscale theory‐based toggle operator. Finally, the mineral image is enhanced through the strategy of enlarging the contrast between the extracted bright and dark image features. Experimental results on different types of mineral images verified that the proposed algorithm could effectively enhance mineral images and performed better than some other algorithms. The enhanced mineral image is clear and contains rich mineral details, whereas the grey scale distribution of the original mineral image is appropriately maintained. This would be useful for the further mineral analysis. Therefore, the proposed algorithm could be widely used for image‐based mineral applications.     

A fuzzy hierarchical operator in the grey wolf optimizer algorithm

The main goal of this paper is to study the performance of the Grey Wolf Optimizer (GWO) algorithm when a new hierarchical operator is introduced in the algorithm. This new operator is basically a hierarchical transformation that is inspired in the hierarchical social pyramid of the grey wolf. This proposed operator is applied to the simulation of the hunting process in the algorithm and has 5 variants that are explained in more detail in this paper (centroid, weighted, based on the fitness and two variants using fuzzy logic). Notably the variants having the greatest impact in the GWO performance are based on the use of fuzzy logic. We also present the motivation and results of experiments, as well as the benchmark functions that were used for the tests that are presented. In addition we are presenting a comparison among all methods for 30, 64 and 128 dimensions and we conclude that the performance of the Hierarchical GWO algorithm is better when using a fuzzy variant of the hierarchical operator.